Hydrocortisone 17-Butyrate , >98.0%(HPLC) , 13609-67-1

Synonym(s):
11β,17,21-Trihydroxypregn-4-ene-3,20-dione 17-butyrate;Cortisol 17-butyrate;Hydrocortisone 17-butyrate

CAS NO.：13609-67-1

Empirical Formula: C25H36O6

Molecular Weight: 432.56

MDL number: MFCD00083364

EINECS: 237-093-4

PRODUCT Properties

• Melting point: 210.0 to 214.0 °C
• Boiling point: 466.2°C (rough estimate)
• Density: 1.0914 (rough estimate)
• refractive index: 1.4593 (estimate)
• storage temp.: Refrigerator
• solubility: Chloroform (Slightly), Methanol (Slightly)
• pka: 12.98±0.10(Predicted)
• form: Solid
• color: White to Off-White
• Merck: 14,4787
• InChIKey: BMCQMVFGOVHVNG-IZBZUILHNA-N
• SMILES: O([C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C)C(=O)CO)C(=O)CCC |&1:1,4,6,16,18,20,23,r|
• CAS DataBase Reference: 13609-67-1(CAS DataBase Reference)

Description and Uses

Hydrocortisone 17-butyrate: a new non-fluorinated topical corticosteroid.
Hydrocortisone 17-butyrate could be used in psoriasis, eczema and other inflammatory dermatoses. It may be found in creams, lotions, ointments, and powders and in ear, nose and eye drops for rhinitis, otitis, and conjunctivitis. In double-blind paired comparisons with other topical corticosteroids, the efficacy of hydrocortisone 17-butyrate 0.1% has generally been indistinguishable from that of triamcinolone acetonide 0.1%, fluocinolone acetonide 0.025% or betamethasone 17-valerate 0.1% in patients with eczema or psoriasis. When applied to the face of patients with atrophy superimposed on rosacea and perioral dermatitis resulting from prolonged use of fluorinated topical corticosteroids, hydrocortisone 17-butyrate 0.1% did not prevent the beneficial effect of systemic tetracycline nor the disappearance of telangiectasis and tended to be more effective than hydrocortisone 1%[1].

Hydrocortisone Butyrate is a topical corticosteroid use to treat a variety of dermatological conditions. It acts as an antiinflammatory, antiproliferative and immunosuppresive agent.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
• WGK Germany: 2
• RTECS: GM9002000
• HS Code: 2937290000