forsynthesis , 553-26-4
Synonym(s):
11β,17α,21-Trihydroxypregn-4-ene-3,20-dione-D4;11β,17α,21-Trihydroxypregn-4-ene-3,20-dione-d4 (9,11,12,12-d4);17-Hydroxycorticosterone-9,11,12,12-d4;17-Hydroxycorticosterone-D4;4-Pregnene-11β,17α,21-triol-3,20-dione-D4
CAS NO.:553-26-4
Empirical Formula: C21H26D4O4
Molecular Weight: 350.49
MDL number: MFCD00144010
EINECS: 694-327-1
Pack Size | Price | Stock | Quantity |
10g | RMB259.96 | In Stock |
|
others | Enquire |
PRODUCT Properties
Melting point: | 211-214 °C |
Flash point: | 9℃ |
storage temp. | -20°C Freezer |
solubility | DMSO (Slightly), Ethanol (Slightly, Heated), Methanol (Slightly, Heated), Water |
form | Solid |
color | White to Off-White |
Description and Uses
Hydrocortisone-d4 is intended for use as an internal standard for the quantification of hydrocortisone/cortisol by GC- or LC-MS. Cortisol, known as hydrocortisone when used as a therapeutic, is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH). It is an agonist at the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR), with an approximately 6- to 10-fold greater affinity for MR. Cortisol production is increased during periods of stress, and it is a major effector molecule in the hypothalamic-pituitary-adrenal axis (HPA) stress response. Cortisol levels increase with age and are often elevated in major depressive disorder, certain forms of hypertension, and Parkinson''s disease.
Anti-inflammatory hormone
Safety
Symbol(GHS) | GHS08 |
Signal word | Warning |
Hazard statements | H361 |
Precautionary statements | P201-P202-P280-P308+P313-P405-P501 |
Hazard Codes | Xn,T,F |
Risk Statements | 63-39/23/24/25-23/24/25-11 |
Safety Statements | 36/37-45-16-7 |
RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
WGK Germany | 3 |