≥97%(HPLC) , 5543-57-7

Synonym(s):
S-(−)-3-Acetonybenzyl)-4-hydroxycoumarin;S-(−)-4-Hydroxy-3-(3-oxo-1-phenybutyl)-2H-1-benzopyran-2-one

CAS NO.：5543-57-7

Empirical Formula: C19H16O4

Molecular Weight: 308.33

MDL number: MFCD00272381

EINECS: 226-907-3

PRODUCT Properties

• Melting point: ≥170 °C
• storage temp.: 2-8°C
• solubility: DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 5 mg/ml
• form: A crystalline solid
• color: white to pale yellow
• CAS DataBase Reference: 5543-57-7(CAS DataBase Reference)

Description and Uses

(–)-Warfarin is a component of (±)-warfarin . It is an anticoagulant that interferes with interconversion of vitamin K and vitamin K epoxide and the role of vitamin K in carboxylation of several clotting cascade proteins, inhibiting the initiation of clotting. In vivo, (–)-warfarin slows formation of the prothrombin complex and exhibits 6.6-fold more potent anticoagulant activity than (+)-warfarin in rats. (–)-Warfarin is primarily metabolized by the cytochrome P450 (CYP) isoform CYP2C9 and genetic polymorphisms in this enyzme, as well as other compounds metabolized by CYP2C9, increase the potential for catastrophic bleeding complications. Formulations containing warfarin have been used to treat and prevent blood clots in atrial fibrillation, heart valve replacement, venous thrombosis, and pulmonary embolism.

The S-(-)-form of Warfarin (W498500). Coumarin anticoagulant.

Safety

• Symbol(GHS): GHS06,GHS08,GHS09
• Signal word: Danger
• Hazard statements: H300+H310+H330-H360D-H372-H411
• Precautionary statements: P202-P264-P273-P280-P302+P352+P310-P304+P340+P310
• Hazard Codes: T
• Risk Statements: 61-48/25-52/53
• Safety Statements: 53-45-61
• RIDADR: UN 2811 6.1/PG 1
• WGK Germany: 3