A1400350
Warfarin , ≥98% , 81-81-2
Synonym(s):
4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin;Coumafene
CAS NO.：81-81-2
Empirical Formula: C19H16O4
Molecular Weight: 308.33
MDL number: MFCD00006854
EINECS: 201-377-6
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 162-164 °C(lit.) |
| Boiling point: | 356°C |
| Density | 1.1411 (rough estimate) |
| vapor pressure | 0.09 at 22 °C (NIOSH, 1997) |
| refractive index | 1.4434 (estimate) |
| Flash point: | 2℃ |
| storage temp. | 2-8°C |
| solubility | Soluble in benzene, 1,4-dioxane (Weast, 1986), and acetone (Sax and Lewis, 1987). Moderately
soluble in methanol, ethanol, isopropanol, and some oils (Windholz et al., 1983). Also soluble in
toluene. |
| form | Crystalline |
| pka | pKa 4.90±0.01(H2O
t = 25±0.5
I = 0.15 (KCl))(Approximate) |
| color | Colorless |
| Odor | odorless |
| Water Solubility | Practically insoluble |
| Merck | 13,10097 |
| BRN | 8868198 |
| Exposure limits | NIOSH REL: TWA 0.1 mg/m3, IDLH 100 mg/m3; OSHA PEL: 0.1
mg/m3; ACGIH TLV: TWA 0.1 mg/m3. |
| LogP | 2.600 |
| CAS DataBase Reference | 81-81-2(CAS DataBase Reference) |
| NIST Chemistry Reference | 3-(Alpha-acetonylbenzyl)-4-hydroxycoumarin(81-81-2) |
| EPA Substance Registry System | Warfarin (81-81-2) |
Description and Uses
(±)-Warfarin (Item No. 13566) is a vitamin K antagonist, a coumarin derivative, and a racemic mixture of (+)-warfarin and (–)-warfarin . It is an anticoagulant that interferes with interconversion of vitamin K and vitamin K epoxide and the role of vitamin K in carboxylation of several clotting cascade proteins, inhibiting the initiation of clotting. Formulations containing warfarin have been used to treat and prevent blood clots in atrial fibrillation, heart valve replacement, venous thrombosis, and pulmonary embolism.
Pesticide and rodenticide
Safety
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
| Signal word | Danger |
| Hazard statements | H300+H310+H330-H360D-H372-H411 |
| Precautionary statements | P202-P264-P273-P280-P302+P352+P310-P304+P340+P310 |
| Hazard Codes | T,T+,Xn,F |
| Risk Statements | 61-48/25-52/53-28-21-36-20/21/22-11 |
| Safety Statements | 53-45-61-52-36/37-28-26-16 |
| RIDADR | UN 2811 6.1/PG 1 |
| OEB | D |
| OEL | TWA: 0.1 mg/m3 |
| WGK Germany | 3 |
| RTECS | GN4550000 |
| HazardClass | 6.1(a) |
| PackingGroup | I |
| HS Code | 29322090 |
| Hazardous Substances Data | 81-81-2(Hazardous Substances Data) |
| Toxicity | EC50 (24-hour) for Daphnia magna 88.8 mg/L (Lilius et al., 1995); acute oral LD50 for rats 186 mg/kg (Hartley and Kidd, 1987), 3 mg/kg (RTECS, 1985) |
| IDLA | 100 mg/m3 |
