Warfarin , ≥98% , 81-81-2

Synonym(s):
4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin;Coumafene

CAS NO.：81-81-2

Empirical Formula: C19H16O4

Molecular Weight: 308.33

MDL number: MFCD00006854

EINECS: 201-377-6

Update time: 2022-07-08

PRODUCT Properties

Melting point:	162-164 °C(lit.)
Boiling point:	356°C
Density	1.1411 (rough estimate)
vapor pressure	0.09 at 22 °C (NIOSH, 1997)
refractive index	1.4434 (estimate)
Flash point:	2℃
storage temp.	2-8°C
solubility	Soluble in benzene, 1,4-dioxane (Weast, 1986), and acetone (Sax and Lewis, 1987). Moderately soluble in methanol, ethanol, isopropanol, and some oils (Windholz et al., 1983). Also soluble in toluene.
form	Crystalline
pka	pKa 4.90±0.01(H2O t = 25±0.5 I = 0.15 (KCl))(Approximate)
color	Colorless
Odor	odorless
Water Solubility	Practically insoluble
Merck	13,10097
BRN	8868198
Exposure limits	NIOSH REL: TWA 0.1 mg/m3, IDLH 100 mg/m3; OSHA PEL: 0.1 mg/m3; ACGIH TLV: TWA 0.1 mg/m3.
LogP	2.600

Description and Uses

(±)-Warfarin (Item No. 13566) is a vitamin K antagonist, a coumarin derivative, and a racemic mixture of (+)-warfarin and (–)-warfarin . It is an anticoagulant that interferes with interconversion of vitamin K and vitamin K epoxide and the role of vitamin K in carboxylation of several clotting cascade proteins, inhibiting the initiation of clotting. Formulations containing warfarin have been used to treat and prevent blood clots in atrial fibrillation, heart valve replacement, venous thrombosis, and pulmonary embolism.

Pesticide and rodenticide

Safety

Symbol(GHS)	GHS06,GHS08,GHS09
Signal word	Danger
Hazard statements	H300+H310+H330-H360D-H372-H411
Precautionary statements	P202-P264-P273-P280-P302+P352+P310-P304+P340+P310
Hazard Codes	T,T+,Xn,F
Risk Statements	61-48/25-52/53-28-21-36-20/21/22-11
Safety Statements	53-45-61-52-36/37-28-26-16
RIDADR	UN 2811 6.1/PG 1
OEB	D
OEL	TWA: 0.1 mg/m3
WGK Germany	3
RTECS	GN4550000
HazardClass	6.1(a)
PackingGroup	I
HS Code	29322090
Toxicity	EC50 (24-hour) for Daphnia magna 88.8 mg/L (Lilius et al., 1995); acute oral LD50 for rats 186 mg/kg (Hartley and Kidd, 1987), 3 mg/kg (RTECS, 1985)
IDLA	100 mg/m3