≥98%(HPLC) , 537049-40-4

Synonym(s):
N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-octanediamide

CAS NO.：537049-40-4

Empirical Formula: C41H43N3O7S

Molecular Weight: 721.86

MDL number: MFCD18452824

PRODUCT Properties

• Melting point: 155 - 157°C
• storage temp.: -20°C
• solubility: DMSO: ≥10mg/mL
• form: powder
• color: white to tan
• InChIKey: BHUZLJOUHMBZQY-UHHSDZQINA-N
• SMILES: C(NC1=CC=C([C@H]2O[C@@H](CSC3=NC(C4=CC=CC=C4)=C(C4=CC=CC=C4)O3)C[C@@H](C3=CC=C(CO)C=C3)O2)C=C1)(=O)CCCCCCC(NO)=O |&1:6,8,29,r|

Description and Uses

Tubacin: an HDAC6 Selective Inhibitor.
Tubacin (tubulin acetylation inducer) is a highly potent and selective, reversible, cell-permeable inhibitor of HDAC6 (IC50=0.004μM). It dose-dependently boosted the release of influenza A virus (IAV) progeny through the increase of acetylated microtubules to effectively move viral components to the plasma membrane. It could reduce the Replication of the Japanese Encephalitis Virus via the Decrease of Viral RNA Synthesis. Tubacin was demonstrated as a host-targeting agent with preventive and therapeutic activities against the Japanese encephalitis virus. Concentration in cell culture experiments typically ranges from 2-50μM[1].

Tubacin is tubulin acetylation inducer that selectively inhibits histone deacetylase (HDAC6).

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P280-P305+P351+P338
• WGK Germany: 3