CI-994 , ≥98% , 112522-64-2
Synonym(s):
4-Acetylamino-N-(2′-aminophenyl)benzamide;Acetyldinaline;Tacedinaline
CAS NO.：112522-64-2
Empirical Formula: C15H15N3O2
Molecular Weight: 269.3
MDL number: MFCD00866266
EINECS: 200-256-5
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB151.20 | In Stock |
|
| 50MG | RMB531.20 | In Stock |
|
| 250MG | RMB1746.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 216.1 °C |
| Boiling point: | 450.6±30.0 °C(Predicted) |
| Density | 1.322±0.06 g/cm3(Predicted) |
| RTECS | CU8702023 |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Soluble in DMSO |
| pka | 13.15±0.70(Predicted) |
| form | powder |
| color | off-white |
| Sensitive | Air Sensitive |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| InChIKey | VAZAPHZUAVEOMC-UHFFFAOYSA-N |
Description and Uses
CI-994 (112522-64-2) is an orally active histone deacetylase (HDAC) inhibitor, IC50 = 0.9, 0.9, 1.2 and >20 μM for HDAC1, HDAC2, HDAC3 and HDAC8 respectively.1 Mediates G1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo.2,3 Increases neuroplasticity during memory extinction.4 Protects beta cells from cytokine-induced apoptosis.4
Tacedinaline is a histone deacetylase (HDAC) inhibitor. Tacedinaline is an anti-cancer agent as HDAC inhibitors block angiogenesis, arrest cell growth, and lead to differentiation and apoptosis in tumor cells. Studies show Tacedinaline to be effective against acute myeloid leukemia in vitro and in vivo when used in combination with conventional anti-cancer agents.
