≥98%(HPLC),solid , 156727-74-1

Synonym(s):
δ Opioid Receptor Agonist, SNC80;(+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide;SNC 80;SNC-80;SNC80 - CAS 156727-74-1 - Calbiochem

CAS NO.：156727-74-1

Empirical Formula: C28H39N3O2

Molecular Weight: 449.63

MDL number: MFCD00672673

PRODUCT Properties

• Melting point: 122-123°C
• Boiling point: 564.8±50.0 °C(Predicted)
• Density: 1.040
• storage temp.: Store at RT
• solubility: DMSO: soluble
• form: solid
• pka: 7.29±0.10(Predicted)
• color: off-white
• Stability: Store in Freezer
• InChIKey: KQWVAUSXZDRQPZ-UMTXDNHDSA-N
• SMILES: C(N(CC)CC)(=O)C1=CC=C([C@@H](N2C[C@@H](C)N(CC=C)C[C@@H]2C)C2=CC=CC(OC)=C2)C=C1

Description and Uses

SNC 80 is a selective nonpeptide agonist of the δ-opioid receptor (K_i = 0.18 nM, IC₅₀ = 2.73 nM) that is over 2,000-fold less effective at the μ-opioid receptor. It effectively activates μ/δ receptor heteromers (EC₅₀ = 52.8 nM) but not κ/δ or μ/κ heteromers. SNC 80 has antinociceptive as well as pro-convulsant effects in vivo.

Rats were administered SNC80 to study the role of nitric oxide synthase in peripheral antinociception mechanism.⁵

Safety

• WGK Germany: 3