≥98%(HPLC) , 168828-58-8

Synonym(s):
(S)-N-[[3-[3-Fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide;PNU100480;PNU-100480

CAS NO.：168828-58-8

Empirical Formula: C16H20FN3O3S

Molecular Weight: 353.41

MDL number: MFCD00937821

PRODUCT Properties

• Melting point: 186-187°C
• Boiling point: 609.0±55.0 °C(Predicted)
• Density: 1.321±0.06 g/cm3(Predicted)
• storage temp.: room temp
• solubility: DMSO: soluble20mg/mL, clear
• form: powder
• pka: 15.53±0.46(Predicted)
• color: white to beige
• optical activity: [α]/D -8 to -12°, c = 1 in chloroform-d

Description and Uses

PNU 100480 is an oxazolidinone antibiotic that is active against multidrug resistant tuberculosis. It inhibits the growth of M. tuberculosis replicating and nonreplicating strains (MIC = ~400 ng/ml for both) and of clinical isolates that are susceptible or resistant to a combination of isoniazid , rifampin (rifampicin; ), ethambutol , and streptomycin (; MICs = ≤0.0625-0.5 mg/L). It also inhibits the growth of P. insidiosum and P. aphanidermatum clinical isolates (MICs = 4-64 μg/ml). PNU 100480 (100 mg/kg per day) decreases the number of colony forming units (CFU) in the lung in a mouse model of systemic nonreplicating M. tuberculosis infection.

Sutezolid is an oxazolidinone antibacterial agent analog. Sutezolid is a promising antimycobacterial agent (tuberculostatic).

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P280-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22
• Safety Statements: 45