synthetic , 14152-28-4

Synonym(s):
(13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid;7-[(1R,2S)-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopent-3-en-1-yl]heptanoic acid;PGA₁

CAS NO.：14152-28-4

Empirical Formula: C20H32O4

Molecular Weight: 336.47

MDL number: MFCD00077858

EINECS: 682-017-9

PRODUCT Properties

• Melting point: 43°C
• Boiling point: 392.93°C (rough estimate)
• Density: 1.0192 (rough estimate)
• refractive index: 1.4434 (estimate)
• storage temp.: -20°C
• solubility: acetone: 10 mg/mL, clear
• form: White solid.
• pka: 4.77±0.10(Predicted)
• color: Off-white
• BRN: 2003401
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Description and Uses

Prostaglandin A₁ (PGA₁) was first isolated as a dehydration product of the PGE₁ compounds found in human semen. It has been shown to cause renal vasodilation, increased urine sodium excretion, and lowered arterial pressure in hypertensive patients. It also has growth-inhibitory activity on tumor cells; the IC₅₀ value for the inhibition of human ovarian cancer is 7.5 μM.

Prostaglandin A1 has been shown to inhibit human immunodeficiency virus type 1 (HIV-1) replication in various cell types. In addition, as a precursor to the anti-inflammatory prostaglandins, it activates pro-inflammatory PGD2 receptor CRTH2 initiating the anti-inflammatory response.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H302-H360F
• Precautionary statements: P201-P301+P312+P330-P308+P313
• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: GY5977900
• F: 8-10
• HS Code: 2937500000