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S8953814

thymidineanalog , 50-90-8

Synonym(s):
CldU

CAS NO.:50-90-8

Empirical Formula: C9H11ClN2O5

Molecular Weight: 262.65

MDL number: MFCD00006531

Pack Size Price Stock Quantity
100mg RMB756.65 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 176-179°C
Density  1.5507 (rough estimate)
refractive index  1.6500 (estimate)
storage temp.  -20°C
solubility  DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form  Solid
pka 7.73±0.10(Predicted)
color  White to Off-White
CAS DataBase Reference 50-90-8(CAS DataBase Reference)

Description and Uses

5-Chloro-2''-deoxyuridine (CldU) is a thymidine analog that is readily incorporated, following phosphorylation, into newly synthesized DNA in place of thymidine. Like 5-bromo-2’-deoxyuridine and 5-iodo-2’-deoxyuridine, CldU can be detected immunologically in cells and tissues. CldU can also be added to cells or tissues sequentially with another thymidine analog to label temporally distinct populations. The insertion of thymidine analogs, including CldU, can significantly alter DNA processing and replication, so these analogs have also been used as mutagens, clastogens, and antiviral compounds.

5-Chloro-2′-deoxyuridine (CldU) is used as a thymidine analog to study the miscoding potential of hypochlorous acid damage to DNA and DNA precursors. When used with antibody based immunofluorescent imaging, 5-Chloro-2′-deoxyuridine incorporation may be used in protocols to identify sites of DNA replication. CldU may be used as a labeling substrate in conjunction with other halogenated uridine labeling substrates such as iododeoxyuridine (IdU).

Safety

Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H302+H312+H332-H351
Precautionary statements  P202-P280-P301+P312-P302+P352+P312-P304+P340+P312-P308+P313
Hazard Codes  Xn
Risk Statements  20/21/22-40
Safety Statements  36/37/39-45
WGK Germany  3
RTECS  YU7400000
HS Code  29349990

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