opticalpurityopticalpurity:≥95%(HPLC,Marfey′sreagent) , 23052-81-5

Synonym(s):
L-AP-4;Cartilage-Derived Morphogenetic Protein-1;CDMP-1;LAP4;L-AP4

CAS NO.：23052-81-5

Empirical Formula: C4H10NO5P

Molecular Weight: 183.1

MDL number: MFCD00083244

EINECS: 200-258-5

PRODUCT Properties

• Melting point: 207-215 °C
• Boiling point: 491.7±55.0 °C(Predicted)
• Density: 1.628±0.06 g/cm3(Predicted)
• storage temp.: 0-6°C
• solubility: H2O : 50 mg/mL (273.07 mM; Need ultrasonic)
• form: solid
• pka: 2.19±0.10(Predicted)
• color: White
• Water Solubility: Soluble to 5 mM in water and to 100 mM in 1eq. NaOH
• Sensitive: Light Sensitive

Description and Uses

Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC₅₀ = 2.5 μM). L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus.

Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM). L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: ES7191700