Adenosine 2′(3′)-monophosphate mixed isomers , 130-49-4

Synonym(s):
Yeast adenylic acid

CAS NO.：130-49-4

Empirical Formula: C10H14N5O7P

Molecular Weight: 347.22

MDL number: MFCD00151215

EINECS: 204-990-7

PRODUCT Properties

• Melting point: 183 °C
• Boiling point: 815.5±75.0 °C(Predicted)
• Density: 2.3200 (rough estimate)
• refractive index: 1.9050 (estimate)
• storage temp.: -20°C
• solubility: <3mg/ml in PBS(pH7.2)
• form: Solid
• pka: pK1: 3.81(+1);pK2: 6.17(0) (25°C)
• color: White
• Water Solubility: 0.5g/L(15 ºC)
• Merck: 157

Description and Uses

Adenosine 2′-monophosphate (2′-AMP) is a metabolite produced from hydrolysis of 2′,3′-cAMP. 2′-AMP inhibits proliferation of preglomerular vascular smooth muscle cells and glomerular mesangial cells via A2B receptors. 2′-AMP is used in the synthesis of a new photoaffinity lable for the coenzyme site of porcine NADP-specific isocitrate dehydrogenase. 2′,3′-cAMP and 2′-AMP represent a new unexplored pathway for adenosine-based cell regulation.

Safety

• WGK Germany: 3
• RTECS: AU7480300
• Toxicity: mouse,LD,intraperitoneal,> 1gm/kg (1000mg/kg),Annals of the New York Academy of Sciences. Vol. 60, Pg. 251, 1954.