AldrichCPR , 4921-82-8

CAS NO.：4921-82-8

Empirical Formula: C14H12N2OS

Molecular Weight: 256.32

MDL number: MFCD00022118

PRODUCT Properties

• Melting point: 159 °C
• Density: 1.290±0.06 g/cm3(Predicted)
• storage temp.: -20°
• solubility: Soluble in DMSO (greater than 50 mg/ml) or in Ethanol (up to 8 mg/ml).
• pka: 9.49±0.70(Predicted)
• form: solid
• color: Off-white
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Description and Uses

TM-2-51 (4921-82-8) is a highly potent and isozyme selective activator of recombinant HDAC8. Increases the activity of HDAC8 by a factor of 12 at 10 μM. No activation of other HDACs is observed. TM-2-51 rescues the activity of catalytically compromised HDAC8 mutants?in vitro.2

Safety

• Symbol(GHS): GHS07,GHS09
• Signal word: Warning
• Hazard statements: H411-H302
• Precautionary statements: P264-P270-P301+P312-P330-P501
• HazardClass: IRRITANT
• HS Code: 2930909899