D-erythro-Sphingosine,N-Acetyl--CAS3102-57-6-Calbiochem , Biologicallyactive,cell-permeable,non-physiologicalceramideanalog. , 3102-57-6

Synonym(s):
C2 Ceramide (d18:1/2:0);N-acetoyl-D-erythro-sphingosine;(2S,3R,4E)-2-(Acetylamino)-4-octadecene-1,3-diol;N-Acetoyl-D-erythro-sphingosine;Acetyl ceramide

CAS NO.：3102-57-6

Empirical Formula: C20H39NO3

Molecular Weight: 341.53

MDL number: MFCD00153903

PRODUCT Properties

• Melting point: 93-96 °C
• Boiling point: 477.13°C (rough estimate)
• Density: 1.0283 (rough estimate)
• refractive index: 1.5614 (estimate)
• storage temp.: −20°C
• solubility: DMSO: soluble
• pka: 13.50±0.20(Predicted)
• form: powder
• color: white
• Stability: Moisture Sensitive

Description and Uses

C2 ceramide is a cell-permeable analog of naturally occurring ceramides. It mediates many diverse biological activities, as do natural ceramides. These processes include differentiation of HL-60 cells, induction of apoptosis, activation of protein phosphatase 2A, and inhibition of the mitochondrial respiratory chain. C2 ceramide also enhances the expression of COX-2 in human dermal fibroblasts and stimulates the growth of bovine aortic smooth muscle cells. The ability of C2 ceramide to destabilize membranes may be responsible for its inhibition of platelet aggregation.

A biologically active, cell permeable, but nonphysiologic ceramide analog. It inhibits cell proliferation and induces monocytic differentiation of HL-60 cells and induces apoptosis. It stimulates protein phosphatase 2A and activates MAP Kinase2

Safety

• Safety Statements: 22-24/25
• WGK Germany: 3
• HS Code: 29241990