N-hexanoyl-D-erythro-sphingosine , >99% , 124753-97-5
Synonym(s):
C₆ Ceramide;C6 ceramide;Caproyl ceramide;N-Caproyl-D -sphingosine;N-hexanoyl-D-erythro-sphingosine
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB771.20 | In Stock |
|
| 25MG | RMB3759.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 76-77°C |
| Boiling point: | 521.03°C (rough estimate) |
| Density | 1.0077 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | -20°C |
| solubility | Soluble in 100% ethanol at 25mg/ml and also in DMSO at 50mg/ml. |
| pka | 13.53±0.20(Predicted) |
| form | Powder |
| color | White |
| Stability: | Freezer -20°C |
| LogP | 7.463 (est) |
Description and Uses
C6 ceramide is a cell-permeable analog of naturally occurring ceramides. With a longer carbon chain than C2 ceramide, it is somewhat more hydrophobic, and may more closely mimic the effects of natural ceramides. C6 ceramide mediates many diverse biological activities including apoptosis, activation of protein phosphatase 2A, and inhibition of the mitochondrial respiratory chain. It also enhances the expression of COX-2 in rat granulosa cells and stimulates the growth of bovine aortic smooth muscle cells. C6 ceramide acts in neuronal axons to inhibit neurite growth.
C6 Ceramide (d18:1/6:0) has been used as a chemotherapeutic agent to test its anti-tumor effect in breast cancer cells and ovarian cancer cell lines. It has also been used to test chemo-sensitization effects in cancer cells.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P280-P261-P271 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| HS Code | 29241990 |
