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S491880

Semustine , 13909-09-6

Synonym(s):
N-(2-Chloroethyl)-N′-(4-methylcyclohexyl)-N-nitrosourea;Methyl-CCNU

CAS NO.:13909-09-6

Empirical Formula: C10H18ClN3O2

Molecular Weight: 247.72

MDL number: MFCD00133811

Pack Size Price Stock Quantity
100mg RMB1181.66 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 64°C (rough estimate)
Density  1.3346 (rough estimate)
refractive index  1.5500 (estimate)
storage temp.  Store at -20°C,unstable in solution, ready to use.
solubility  Soluble in DMSO
form  Solid
pka 10.89±0.40(Predicted)
color  Light yellow to yellow
CAS DataBase Reference 13909-09-6
IARC 1 (Vol. Sup 7, 100A) 2012
EPA Substance Registry System 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (13909-09-6)

Description and Uses

In October 2008, scientists of the International Agency for Research on Cancer reaffirmed the Group 1 classification ‘carcinogenic to humans’ of 20 pharmaceutical agents including semustine. Me-CCNU [1-(2-chloroethyl)-3- (4-methylcyclohexyl)-1-nitrosourea] is an alkylating agent of the nitrosourea group, used alone or in combination with other chemotherapeutic agents to treat several types of cancers, including primary and metastatic brain tumors, Lewis lung tumor, and L1210 leukemia. It has also been used to treat cancers of the digestive tract, Hodgkin lymphoma, malignant melanoma, and epidermoid carcinoma of the lung. Doses varied depending on the type of cancer and body weight of the individual. The typical oral dose was 125–200 mgm-2 body surface area, and was repeated every 6 weeks. An alternative regimen was reported to be 200–225 mg m-2 orally every 6–8 weeks. Me-CCNU is a bifunctional antineoplastic agent that undergoes spontaneous chemical decomposition, yielding electrophilic compounds and ultimately inducing alkylation and carbamoylation of cellular macromolecules, including DNA and protein.

Commonly used in pharmacological studies involving: • ;Nutrient-sensitized screening for drugs that shift the energy metabolism from mitchondrial respiration to glycolysis1• ;CEOP regimen with semustine used as induction chemotherapy in patients with lymphoma2• ;Investigations into its use for chemotherapy3,4

Safety

Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H300-H311+H331-H315-H319-H335-H350-H360
Precautionary statements  P202-P280-P301+P310-P302+P352+P312-P304+P340+P311-P305+P351+P338
Hazard Codes  T
Risk Statements  45-46-23/24/25-36/37/38
Safety Statements  53-22-26-36/37/39-45
RIDADR  3249
WGK Germany  3
RTECS  YS5000000
HazardClass  6.1(a)
PackingGroup  II
Hazardous Substances Data 13909-09-6(Hazardous Substances Data)
Toxicity child,LDLo,oral,5550mg/kg/30W (5550mg/kg),KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI,New England Journal of Medicine. Vol. 300, Pg. 1200, 1979.

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