1.0 mg/mLinmethanol,ampuleof1 mL,certifiedreferencematerial,Cerilliant , 59467-70-8

Synonym(s):
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine;Midazolam-d₄ maleate solution

CAS NO.：59467-70-8

Empirical Formula: C18H13ClFN3

Molecular Weight: 325.77

MDL number: MFCD08272801

EINECS: 261-774-5

PRODUCT Properties

• Melting point: 161-164°C
• Boiling point: 496.9±55.0 °C(Predicted)
• Density: 1.3136 (estimate)
• Flash point: 9 °C
• storage temp.: Controlled Substance, -20°C Freezer
• solubility: Practically insoluble in water, freely soluble in acetone and in ethanol (96 per cent), soluble in methanol.
• form: Solid:crystalline
• pka: pKa 1.7±0.1;6.15± 0.1 (Uncertain)
• Water Solubility: 54mg/L(24 ºC)
• BCS Class: 1
• LogP: 2.73
• CAS DataBase Reference: 59467-70-8(CAS DataBase Reference)
• NIST Chemistry Reference: Midazolam(59467-70-8)

Description and Uses

Midazolam is the most commonly used parenteral sedative in anaesthetic practice. The structure of midazolam is altered by local changes in pH (tautomerism), and the two different forms confer either water or lipid solubility to the drug . At pH<4 the benzodiazepine nucleus opens because of an ionisable amine group in the molecule's structure, and this increases water solubility. At plasma pH the amine group is incorporated back into the unionised ring form of the molecule, which is highly lipid soluble and diffuses rapidly into the brain. A concentrated preparation (5mgml ?1 ) is available for i.m. injection and absorption is rapid compared with diazepam.

Anti-Depressant

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301
• Precautionary statements: P264-P270-P301+P310-P405-P501
• Hazard Codes: F,T
• Risk Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 7-16-36/37-45
• RIDADR: 3249
• WGK Germany: 2
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 2933910000
• Hazardous Substances Data: 59467-70-8(Hazardous Substances Data)
• DEA Controlled Substances: CSCN: 2884; CAS SCH: IV; NARC: N