EuropeanPharmacopoeia(EP)ReferenceStandard , 148553-50-8
Synonym(s):
(S)-3-(Aminomethyl)-5-methylhexanoic acid;(S)-3-(Aminomethyl)-5-methylhexanoic acid; (S)-3-Isobutyl-γ-aminobutyric acid;3-Isobutyl GABA;,
CAS NO.：148553-50-8
Empirical Formula: C8H17NO2
Molecular Weight: 159.23
MDL number: MFCD00917044
EINECS: 604-639-1
| Pack Size | Price | Stock | Quantity |
| Y0001805 | RMB1157.70 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 194-196°C |
| alpha | D23 +10.52° (c = 1.06 in water) |
| Boiling point: | 274.0±23.0 °C(Predicted) |
| Density | 0.997±0.06 g/cm3(Predicted) |
| Flash point: | 9℃ |
| storage temp. | 2-8°C |
| solubility | deionized water: ≥10mg/mL |
| pka | 4.23±0.10(Predicted) |
| form | white powder |
| Water Solubility | Soluble to 100 mM in water |
| BCS Class | 1 |
| InChI | InChI=1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1 |
| InChIKey | AYXYPKUFHZROOJ-ZETCQYMHSA-N |
| SMILES | C(O)(=O)C[C@@H](CN)CC(C)C |
| CAS DataBase Reference | 148553-50-8(CAS DataBase Reference) |
Description and Uses
Pregabalin (Lyrica), a derivative of GABA that is closely related to gabapentin, has undergone extensive research for its efficacy in treating conditions such as generalized anxiety disorder (GAD), fibromyalgia, neuropathic pain, and partial complex seizures. It seems to have a more targeted effect on the a2-δ subunit of calcium channels in the brain compared to gabapentin. Pregabalin was granted FDA approval at the end of 2004 for the treatment of neuropathic pain and epilepsy. In 2008, it became the first medication approved for the management of fibromyalgia. Although pregabalin was approved for GAD treatment in the European Union in 2006, it has not yet received FDA approval for GAD in the United States as of the time of writing.
Pregabalin is an anticonvulsant drug used for neuropathic pain, as an adjunct therapy for partial seizures, and in generalized anxiety disorder. It was designed as a more potent successor to gabapentin. Pregabalin is marketed by Pfizer under the trade nam
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H336-H361 |
| Precautionary statements | P201-P202-P261-P271-P280-P308+P313 |
| Hazard Codes | Xn,T,F |
| Risk Statements | 63-48/22-39/23/24/25-23/24/25-11 |
| Safety Statements | 22-36/37-45-16-7 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| HS Code | 29224999 |
| Hazardous Substances Data | 148553-50-8(Hazardous Substances Data) |
