ANTU , PESTANAL ,analyticalstandard , 86-88-4

Synonym(s):
N-(1-Naphthyl)thiourea

CAS NO.：86-88-4

Empirical Formula: C11H10N2S

Molecular Weight: 202.28

MDL number: MFCD00041824

EINECS: 201-706-3

Update time: 2022-07-08

PRODUCT Properties

Melting point:	193 °C
Boiling point:	377.6±25.0 °C(Predicted)
Density	1.333
refractive index	1.5500 (estimate)
storage temp.	Poison room
solubility	4.3 and 86 g/L in acetone and triethylene glycol, respectively (Windholz et al., 1983)
pka	13.12±0.70(Predicted)
form	Crystals or Crystalline Powder
color	Grayish to beige-brown
Odor	bitter taste
Water Solubility	600 mg/L at 20 °C (quoted, Windholz et al., 1983)
Merck	14,722
BRN	778118
Exposure limits	NIOSH REL: TWA 0.3 mg/m3, IDLH 100 mg/m3; OSHA PEL: TWA 0.3 mg/m3

Description and Uses

a-Naphthylthiourea (ANTU; also called DIRAX) is toxic by inhalation, ingestion, or skin contact. Due to its very narrow spectrum of activity, production was discontinued a long time ago. Exposure to ANTU causes pulmonary edema; therefore, it is often used as an experimental pneumotoxin. ANTU is a graycolored, prism-shaped, odorless powder with a bitter taste. It has a molecular weight of 202.28 and melting point of 200 ℃ and does not ignite readily. However, on interaction with potential oxidizing agents, it may cause fire and explosions, which can lead to hazardous decomposition products such as sulfur dioxide, nitrogen dioxide, and carbon monoxide. The structure of ANTU contains the naphthalene chromophore, which absorbs UV light at ～311 nm. This suggests that ANTU can undergo photolysis.

ANTU an organosulfur is a derivative of thiourea. It is a singledose rodenticide that is specifically used against Norway rats as a bait. However, it is futile against all other species of rodents. Because of its tendency to cause resistance and specificity only toward Norway rodents, this poison rapidly lost popularity and is no longer manufactured in the United States.

Safety

Symbol(GHS)	GHS06,GHS08
Signal word	Danger
Hazard statements	H300-H351
Precautionary statements	P201-P202-P264-P270-P280-P301+P310
Hazard Codes	T+
Risk Statements	28-40
Safety Statements	28-36/37-45-25-23
RIDADR	1651
OEB	C
OEL	TWA: 0.3 mg/m3
WGK Germany	2
RTECS	YT9275000
TSCA	Yes
HazardClass	6.1
PackingGroup	I
HS Code	29309090
Toxicity	Acute oral LD50 for Norwegian rats 6–8 mg/kg (Hartley and Kidd, 1987).
IDLA	100 mg/m3