MISSION?esiRNA , targetingmouseNmur1

Synonym(s):
Filimarisin

CAS NO.：

Empirical Formula: C35H58O11

Molecular Weight: 654.83

MDL number: MFCD30742956

PRODUCT Properties

• Melting point: 163-180° (Bergy, Eble)
• alpha: D25 -245° (c = 0.8 in DMF)
• Boiling point: 913.9±65.0 °C(Predicted)
• Density: 1.161±0.06 g/cm3(Predicted)
• storage temp.: −20°C
• solubility: Soluble in Methanol (up to 10 mg/ml)
• form: solid
• pka: 12.77±0.70(Predicted)
• color: White or light yellow
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in methanol may be stored under inert gas at -20°C for up to 2 months.

Description and Uses

Cholesterol is both an important structural component of cell membranes and an early intermediate in hormone and bile acid biosynthesis. The localization and measurement of cholesterol in cells is therefore of great interest. Filipin is the collective name given to four isomeric polyene macrolides isolated from cultures of S. filipinensis; Filipin III is the predominant isomer and the one used in most studies. Filipin binds to cholesterol in membranes, forming ultrastructural aggregates and complexes which can be visualized by freeze-fracture electron microscopy. The binding of cholesterol also decreases the intrinsic fluorescence of Filipin, and this property has also been used to detect cholesterol in membrane fractions.

Produces arthritis rapidly in rabbits: Pras, Weissman, Drug Trade News, July 4, 1966, p 40; as a sterol probe in freeze-fracture cytochemistry.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: RN9800000
• HS Code: 2932990090