≥90%(HPLC),powder , 201608-14-2
Synonym(s):
Ac-DEVD-AFC
CAS NO.：201608-14-2
Empirical Formula: C30H34F3N5O13
Molecular Weight: 729.61
MDL number: MFCD01310970
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB1719.41 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 1152.7±65.0 °C(Predicted) |
| Density | 1.495±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | H2O: 1 mg/mL |
| form | powder |
| pka | 4.09±0.10(Predicted) |
| color | white |
Description and Uses
Ac-DEVD-AFC is a fluorogenic substrate for caspase-3 (CPP32) and related cysteine proteases, which emits a blue to green shift in fluorescence. It also acts as a substrate for granzyme B-processed caspase-6, caspase-7, caspase-8, and caspase-10. It is known that Ac-DEVD-AFC has a greater Stokes'' shift than Ac-DEVD-AMC once it has been cleaved. Since caspase-3 is an effector caspase, it is involved in the cleavage of many substrates which promote apoptosis. This indicator excites light at 400 nm and emits light at 505 nm. In addition, Ac-DEVD-AFC is modeled after Asp216 on caspase-3, the PARP cleavage site. Ac-DEVD-AFC is an essential indicator used to monitor the cellular effects of caspase-3.
Safety
| WGK Germany | 3 |
