Content measurement , 357-57-3
Synonym(s):
(-)-Brucine;2,3-Dimethoxy strychnine
CAS NO.：357-57-3
Empirical Formula: C23H26N2O4
Molecular Weight: 394.46
MDL number: MFCD00005942
EINECS: 206-614-7
PRODUCT Properties
| Melting point: | 175-178 °C (dec.)(lit.) |
| Boiling point: | 518.67°C (rough estimate) |
| alpha | -118 º (c=2.5 in chloroform) |
| Density | 1.2119 (rough estimate) |
| refractive index | 1.6300 (estimate) |
| storage temp. | Store at RT |
| solubility | >15.6mg/mL in DMSO |
| pka | 8.28(at 25℃) |
| form | Powder |
| color | White to light beige |
| Water Solubility | Soluble in alcohol, chloroform, and benzene, slightly soluble in water, ether, and glycerol |
| Merck | 14,1455 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| LogP | 0.980 |
Description and Uses
As a Chinese medicine, brucine was firstly recorded in Compendium of Materia Medica. The Chinese name for brucine is “Maqian” because it looks like ancient coins with horse icon, where “Ma” refers to “horse” and “qian” refers to “coins.” This traditional Chinese herb has cold, bitter, and toxic properties. It can be used to treat typhoid fever, throat pain, and lumps. Brucine is mainly extracted from the traditional Chinese medicine “Maqian.” In 1819, Pelletier and Caventou firstly isolated the alkaline brucine from the seeds and bark of Strychnos nux-vomica L.?Brucine is the dry and mature seeds of Loganiaceae Evergreen tree plants including Strychnos nux-vomica L. and Strychnos pierriana A.W. Hill.
Brucine is used as a denaturing alcohol, lubricant additive, separation of racemic mixtures. Proposed to reduce inflammatory mediators including COX-2, PGE2 and thromboxane B2. Able to induce cell apoptosis, with cytotoxic and antiproliferative effects.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Warning |
| Hazard statements | H300-H330-H412 |
| Precautionary statements | P301+P310a-P304+P340-P320-P330-P405-P501a |
| Hazard Codes | T+ |
| Risk Statements | 26/28-52/53 |
| Safety Statements | 13-45-61 |
| RIDADR | UN 1570 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | EH8925000 |
| TSCA | Yes |
| HazardClass | 6.1(a) |
| PackingGroup | I |
| HS Code | 29399900 |
