6-(Bromomethyl)pteridine-2,4-diaminehydrobromide , 90% , 52853-40-4

CAS NO.：52853-40-4

Empirical Formula: C7H8Br2N6

Molecular Weight: 335.987

MDL number: MFCD09833976

EINECS: 692-499-2

PRODUCT Properties

• Melting point: >195°C (dec.)
• storage temp.: -20°C Freezer
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• color: Light Brown to Brown
• InChI: InChI=1S/C7H7BrN6.BrH/c8-1-3-2-11-6-4(12-3)5(9)13-7(10)14-6;/h2H,1H2,(H4,9,10,11,13,14);1H
• InChIKey: KMQIBGKVZDBGAH-UHFFFAOYSA-N
• SMILES: NC1=NC(N)=NC2=NC=C(CBr)N=C12.Br

Description and Uses

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide is a potent inhibitor of the enzyme nitroaldolase (EC 1.2.1.22) and has been shown to inhibit cell growth in murine leukemia cells. This reaction is mediated by the addition of bromide to isobutyl esters, leading to a benzyl ester intermediate which undergoes an electrophilic attack on nitroaldolase. The mechanism of action for this drug involves the inhibition of membrane transport and chloride ion influx, which are necessary for the proliferation of tumor cells. 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide also inhibits DNA synthesis through its effects on thymidylate synthase, preventing nucleotide production from thymine and dihydrofolate reductase activity.

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide can be used as organic synthesis intermediate and pharmaceutical intermediate.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338