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A5527212

Methotrexate , ≥98% , 59-05-2

Synonym(s):
Methotrexate;MTX;Methotrexate hydrate;Methylaminopterin;Methylaminopterin hydrate

CAS NO.:59-05-2

Empirical Formula: C20H22N8O5

Molecular Weight: 454.45

MDL number: MFCD00064370

EINECS: 200-413-8

Pack Size Price Stock Quantity
1g RMB50.40 In Stock
500MG RMB52.00 In Stock
5G RMB151.20 In Stock
25g RMB515.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 195°C
Boiling point: 561.26°C (rough estimate)
alpha  +17~+24°(D/20℃)(c=1,Na2CO3 soln.)(calculated on the dehydrous basis)
Density  1.4080 (rough estimate)
refractive index  1.6910 (estimate)
Flash point: 11℃
storage temp.  Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility  H2O: insoluble
form  powder
pka pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain)
color  Light yellow to yellow
Water Solubility  Insoluble. <0.1 g/100 mL at 19 ºC
Sensitive  Light Sensitive & Hygroscopic
Merck  14,5985
BRN  70669
BCS Class 3
Stability: Stable, but light sensitive and hygroscopic. Incompatible with strong acids, strong oxidizing agents. Store at -15C or below.
InChIKey FBOZXECLQNJBKD-ZDUSSCGKSA-N
CAS DataBase Reference 59-05-2(CAS DataBase Reference)
IARC 3 (Vol. 26, Sup 7) 1987
NIST Chemistry Reference Methotrexate(59-05-2)
EPA Substance Registry System Methotrexate (59-05-2)

Description and Uses

Methotrexate is an orange-brown crystalline powder. Molecular weight= 454.50; Freezing/Melting point=185204℃ (decomposes). Insoluble in water.

Methotrexate is used to treat severe lymphatic leukemia, choriocarcinoma, non-Hodgkin’s lymphoma, bone carcinoma, as well as head, neck, breast, and lung tumors.

Safety

Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H315-H319-H341-H360D
Precautionary statements  P201-P301+P310+P330-P302+P352-P305+P351+P338
Hazard Codes  T,F
Risk Statements  61-25-36/38-46-39/23/24/25-23/24/25-11
Safety Statements  53-26-36/37-45-36/37/39-36-16
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  MA1225000
3-8-10
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29335995
Hazardous Substances Data 59-05-2(Hazardous Substances Data)
Toxicity LD50 oral in rat: 135mg/kg

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