Aminopterin , 10mMinDMSO , 54-62-6

Synonym(s):
Aminopterin;(S)-2-{4-[(2,4-Diaminopteridin-6-yl)methylamino]benzamido}pentanedioic acid;4-Aminofolic acid;4-Amino-PGA;4-Aminopteroyl-L-glutamic acid

CAS NO.：54-62-6

Empirical Formula: C19H20N8O5

Molecular Weight: 440.41

MDL number: MFCD00036692

EINECS: 200-209-9

PRODUCT Properties

• Melting point: 225 °C
• alpha: 18 º (c=1% in 0.1N NaOH)
• Boiling point: 551.67°C (rough estimate)
• Density: 1.4378 (rough estimate)
• refractive index: 1.6910 (estimate)
• Flash point: 87℃
• storage temp.: -20°C
• solubility: 2 M NaOH: 50 mg/mL
• form: powder
• pka: pKa 5.5 (Uncertain)
• color: yellow
• Merck: 14,472
• BRN: 69045

Description and Uses

Aminopterin is an amino derivative of folic acid, which was once used as an antineoplastic agent in the treatment of pediatric leukemia. In the 1950's its production was discontinued in favor of methotrexate, which is less potent but less toxic. Off label, aminopterin has also been used in the treatment of psoriasis. Clinicians need to be aware of the characteristic teratologic effects of aminopterin and methotrexate.

antineoplastic, antirheumatic, folic acid antagonist

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H300-H360
• Precautionary statements: P201-P280-P301+P330+P331+P310-P308+P313
• Hazard Codes: T+
• Risk Statements: 61-28-63-26/27/28
• Safety Statements: 53-28-36/37-45-36/37/39-22
• RIDADR: UN 2811 6.1/PG 1
• WGK Germany: 3
• RTECS: MA1050000
• F: 8-10-23
• HazardClass: 6.1(a)
• PackingGroup: I
• HS Code: 29339900
• Toxicity: LDLo orl-rat: 2500 mg/kg JPETAB 95,303,49