2-[2-(2-Azidoethoxy)ethoxy]ethanamine , 95% , 166388-57-4

CAS NO.：166388-57-4

Empirical Formula: C6H14N4O2

Molecular Weight: 174.2

MDL number: MFCD13189985

PRODUCT Properties

• solubility: Soluble in Water, DMSO, DMF, DCM
• form: Liquid
• color: Colorless to light yellow
• CAS DataBase Reference: 166388-57-4

Description and Uses

Azido-PEG2-amine is a bifunctional crosslinker containing an amino and an azide group. The amino group is reactive with carboxylic acids, activated NHS esters,. The azide(N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG2-C2-amine is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. Azido-PEG2-C2-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Safety

• Symbol(GHS): GHS05
• Signal word: Danger
• Hazard statements: H314
• Precautionary statements: P260-P280
• HS Code: 2929900090