Fmoc-15-amino-4,7,10,13-tetraoxapentadecacanoic acid , 98% , 557756-85-1
CAS NO.：557756-85-1
Empirical Formula: C26H33NO8
Molecular Weight: 487.54
MDL number: MFCD06656472
EINECS: 1592732-453-0
| Pack Size | Price | Stock | Quantity |
| 250mg | RMB144.00 | In Stock |
|
| 1G | RMB242.40 | In Stock |
|
| 5G | RMB1039.20 | In Stock |
|
| 10g | RMB1880.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 682.1±55.0 °C(Predicted) |
| Density | 1.219 |
| storage temp. | -20°C |
| solubility | Soluble in DMSO, DCM, DMF |
| form | solid or viscous liquid |
| pka | 4.28±0.10(Predicted) |
| color | Colorless to light yellow |
Description and Uses
Fmoc-N-amido-PEG4-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Fmoc-NH-PEG4-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG4-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H319-H335-H302+H312+H332-H315 |
| Precautionary statements | P280-P301+P312-P362+P364 |
| Safety Statements | 24/25 |
| HS Code | 29225090 |
