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M8229147

Quinupristin , 98% , 120138-50-3

CAS NO.:120138-50-3

Empirical Formula: C53H67N9O10S

Molecular Weight: 1022.23

MDL number: MFCD00865105

Pack Size Price Stock Quantity
10mg RMB6317.60 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: ~200°
form  Solid
color  White to off-white

Description and Uses

Quinupristin is a streptogramin antibiotic that blocks peptide bond formation and peptide extension in bacteria. Quinupristin is usually combined with another streptogramin antibiotic, dalfopristin , to produce quinupristin-dalfopristin complex , known commercially as Synercid. While both quinupristin and dalfopristin have bacteriostatic effects, they act synergistically to kill Gram-positive bacteria, as well as some Gram-negative and anaerobic bacteria.

Quinupristin is a semi-synthetic analogue of virginiamycin B (ostreogrycin B, pristinamycin IA, streptogramin B) formed by a Mannich condensation and elimination to generate an exocyclic methylene alpha to the ketone of the 4-piperidinone. Addition of quinucidinylthiol to the methylene group affords quinupristin. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Quinupristin is used commercially in synergistic combination with dalfopristin (30:70). There is little published data on the synthesis, biological or antibiotic activity of quinupristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.

Safety

Hazardous Substances Data 120138-50-3(Hazardous Substances Data)

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