M8226547
8-Hydroxy-efavirenz , 97% , 205754-33-2
CAS NO.：205754-33-2
Empirical Formula: C14H9ClF3NO3
Molecular Weight: 331.67
MDL number: MFCD09840726
| Pack Size | Price | Stock | Quantity |
| 10mg | RMB17280.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 144-154°C |
| Boiling point: | 373.6±42.0 °C(Predicted) |
| Density | 1?+-.0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Acetonitrile: soluble; DMSO: soluble; Methanol: soluble |
| form | A solid |
| pka | 7.18±0.40(Predicted) |
| color | White to off-white |
Description and Uses
8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz . 8-hydroxy Efavirenz is formed when efavirenz is metabolized by the cytochrome P450 (CYP) isoform CYP2B6. It induces apoptosis in rat primary hippocampal neurons and loss of dendritic spines in rat primary hippocampal neuronal cultures when used at a concentration of 0.01 μM.
8-Hydroxy Efavirenz is a metabolite of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor.
