KT5720 , BR , 108068-98-0

Synonym(s):
;InSolution KT5720 - CAS 108068-98-0 - Calbiochem;KT5720 - CAS 108068-98-0 - Calbiochem;PKA Inhibitor VII

CAS NO.：108068-98-0

Empirical Formula: C32H31N3O5

Molecular Weight: 537.61

MDL number: MFCD09878277

EINECS: 810-587-2

PRODUCT Properties

• Boiling point: 715.0±60.0 °C(Predicted)
• Density: 1.49±0.1 g/cm3(Predicted)
• storage temp.: −20°C
• solubility: methanol: 5 mg/mL
• form: powder
• pka: 11.96±0.40(Predicted)
• color: white
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Description and Uses

Protein kinase A (PKA) regulates multiple signal transduction events via protein phosphorylation and is integral to all cellular responses involving the cyclic AMP second messenger system. KT 5720 is one of a family of compounds synthesized by the fungus Nocardiopsis sp. It blocks PKA signaling through competitive inhibition of ATP with a K_i value of 60 nM. Reported IC₅₀ values vary widely depending upon ATP concentration tested and can range from 56 nM (low ATP) to 3 μM (physiologic ATP). Non-specific effects of KT 5720 include inhibition of phosphorylase kinase, PDK1, MEK, MSK1, PKBα, and GSK3β at concentrations as effective as or more potent than that for inhibition of PKA.

KT 5720 is a potent, specific and cell-permeable inhibitor of PKA.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280-P271
• Hazard Codes: Xi
• Risk Statements: 36/38
• Safety Statements: 26-36
• WGK Germany: -
• F: 10
• HS Code: 29419090