M8154247
Picrotin , 98% , 21416-53-5
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB1771.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 256-258°C |
| alpha | D -64.7° (c = 2.31 in abs alc) |
| Boiling point: | 595.8±50.0 °C(Predicted) |
| Density | 1.59 |
| storage temp. | 2-8°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml |
| pka | 13.28±0.60(Predicted) |
| form | Solid |
| color | White to off-white |
| EPA Substance Registry System | Picrotin (21416-53-5) |
Description and Uses
Picrotin is a natural picrotoxane that antagonizes glycine receptors (GlyRs; IC50s = 57 and 117 μM for α1 and α2 homodimeric GlyRs, respectively). It also inhibits α3 homodimeric GlyRs. Picrotin is inactive in inhibiting γ-aminobutyric acid (GABA) type A and type C receptors. Picrotin occurs in the natural plant-derived poison picrotoxin , equimolar with picrotoxinin.
GABAa receptor antagonist
Safety
| WGK Germany | 3 |
| RTECS | TJ8800000 |
| Toxicity | LD50 i.p. in mice: 135 mg/kg (Jarboe) |
