N-Arachidonoyl-L-Serine(ARA-S) , 98% , 187224-29-9

CAS NO.：187224-29-9

Empirical Formula: C23H37NO4

Molecular Weight: 391.54

MDL number: MFCD08062151

PRODUCT Properties

• Boiling point: 607.6±55.0 °C(Predicted)
• Density: 1.027±0.06 g/cm3(Predicted)
• storage temp.: Store at -20°C
• solubility: DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 2 mg/ml
• pka: 3.26±0.10(Predicted)

Description and Uses

Arachidonoyl amides of both amino acids and neurotransmitters such as dopamine have been previously reported in the literature. N-Arachidonoyl-L-serine (ARA-S) is one such recently isolated endocannabinoid with an unusual activity profile. ARA-S does not bind to central cannabinoid (CB₁) and peripheral cannabinoid (CB₂) receptors or vanilloid receptor 1 (VR1). Like cannabidiol, ARA-S (5 mg/kg) antagonizes the hypotensive effects of a 10 mg/kg IV bolus of abnormal cannabidiol (Abn-CBD) in an anesthetized rat blood pressure model. However, similar to Abn-CBD, ARA-S relaxes isolated rat mesenteric arteries and abdominal aorta as well as increases phosphorylation of Akt and mitogen-activated protein kinase (MAPK) in HUVEC. The precise mechanisms of action by ARA-S and Abn-DBD in various vascular preparations appears to be different and requires further investigation.

N-Arachidonoyl-L-serine is a novel neuroprotective endocannabinoid with weak affinity for CB1 and CB2 cannabinoid receptors. It is also a pro-angiogenic factor and a vessel dilator. Shows proneurogenic properties in vitro and invivo in mice model of traumatic brain injury. (1) Exhibits neuroprotection via ERK and Akt phosphorylation and induction of their downstream antiapoptotic pathways (2)

Safety

• Symbol(GHS): GHS02,GHS08
• Signal word: Danger
• Hazard statements: H225-H350
• Precautionary statements: P201-P202-P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P308+P313-P370+P378-P403+P235-P405-P501