Amauromine , 98% , 88360-87-6

CAS NO.：88360-87-6

Empirical Formula: C32H36N4O2

Molecular Weight: 508.662

MDL number: MFCD01939909

PRODUCT Properties

• Boiling point: 689.9±55.0 °C(Predicted)
• Density: 1.28±0.1 g/cm3(Predicted)
• storage temp.: Store at -20°C
• solubility: DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
• form: A solid
• pka: 3.26±0.60(Predicted)
• color: Brown

Description and Uses

Amauromine is a neutral antagonist of the cannabinoid (CB) receptor CB₁ that is selective for CB₁ (K_i = 178 nM; K_b = 66.6 nM) over CB₂, with no activity at CB₂ receptors at concentrations up to 10 μM. It is also an antagonist of GPR18 (IC₅₀ = 3.74 μM). Amauromine has vasodilatory activity.

Amauromine is a CB1 and Calcium Channel antagonist.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302+H312+H332
• Precautionary statements: P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P321-P330-P362+P364-P501
• Toxicity: LD50 intraperitoneal in mouse: > 200mg/kg