Z-Asp-CH2-DCB , ≥99% , 153088-73-4

CAS NO.：153088-73-4

Empirical Formula: C20H17Cl2NO7

Molecular Weight: 454.26

MDL number: MFCD00674885

PRODUCT Properties

• Boiling point: 674.2±55.0 °C(Predicted)
• Density: 1.440±0.06 g/cm3(Predicted)
• storage temp.: −20°C
• solubility: Soluble in DMSO (up to 25 mg/ml).
• form: White to off-white powder.
• pka: 4.01±0.19(Predicted)
• color: white
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Description and Uses

Z-Asp-CH2-DCB is a peptide originally synthesized for its ability to inactivate the interleukin-1β-converting enzyme, which is the homolog of the C. elegans positive regulator of apoptosis CED-3. Z-Asp-CH2-DCB has been shown to block apoptosis by nonselectively inhibiting caspase activity. At 1-100 μM, it can dose-dependently block the production of IL-1β, TNF-α, IL-6, and IFN-γ by human peripheral blood mononuclear cells as well as inhibit T cell proliferation.

Z-Asp-2,6-dichlorobenzoyloxymethylketone is a broad Caspase Inhibitor.

Safety

• WGK Germany: 3