Biotin-PEG3-SS-DBCO , 95% , 1430408-09-5

CAS NO.：1430408-09-5

Empirical Formula: C42H56N6O8S3

Molecular Weight: 869.12

MDL number:

PRODUCT Properties

• Boiling point: 1194.2±65.0 °C(Predicted)
• Density: 1.33±0.1 g/cm3(Predicted)
• solubility: DMSO : 100 mg/mL (115.06 mM; Need ultrasonic)
• form: Oil
• pka: 13.90±0.40(Predicted)
• color: Light yellow to brown

Description and Uses

DBCO-S-S-PEG3-biotin is a cleavable reagent for introduction of a biotin moiety to azide-containing biomolecules using copper-free Click Chemistry. PEG spacer arm provides better solubility to the labeled molecules in aqueous media. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP.

DBCO-S-S-PEG3-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-S-S-PEG3-biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.