Tamarixetin , 97% , 603-61-2
Synonym(s):
3,3′,5,7-Tetrahydroxy 4′-methoxyflavone;3,5,7-Trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one;4′-Methylquercetin;Quercetin 4′-methyl ether;Tamaraxetin
CAS NO.：603-61-2
Empirical Formula: C16H12O7
Molecular Weight: 316.26
MDL number: MFCD00017308
EINECS: 210-050-7
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB390.40 | In Stock |
|
| 5mg | RMB1440.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 265-268°C |
| Boiling point: | 601.8±55.0 °C(Predicted) |
| Density | 1.634±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: Slightly Soluble; Methanol: Slightly Soluble |
| form | A solid |
| pka | 6.31±0.40(Predicted) |
| color | Yellow to brown |
| LogP | 2.420 (est) |
Description and Uses
4''-O-methyl Quercetin is a flavonoid isolated from C. ordata with anticancer and antiplasmodial activity. 4''-O-methyl Quercetin is a major metabolite of quercetin (Item No. 10005169) that inhibits the viability of HL-60, U937, MOLT-3, Raji, K562, MCF-7, SK-MEL-1, and A549 human tumor cell lines with IC50 values ranging from 5.5-24.1 μM. It induces G2-M arrest and inhibits tubulin polymerization in vitro in a dose-dependent manner. 4''-O-methyl Quercetin inhibits breast cancer resistance protein (BCRP/ABCG2; IC50 = 40 nM in a vesicular transport assay) with no cellular toxicity indicating potential for use in overcoming multidrug resistance in chemotherapy. 4''-O-methyl Quercetin also reduces in vitro proliferation of chloroquine-resistant P. falciparum (IC50 = 4.8 μM) and suppresses infection in mice (65-81% suppression at 2.5-5 mg/kg dose).
A major metabolite of the flavanoid Quercetin (Q509500) with antioxidant properties. It helps to protect H9c2 cardiomyoblasts against H2O2-induced oxidative stress via the modulation of PI3K/Akt and ERK1/2 signaling pathways.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 |
| Risk Statements | 22 |
| Safety Statements | 22-45 |
