TimololMaleate , 99% , 26921-17-5

Synonym(s):
S-(−)-1-(t-Butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol maleate salt;Timolol hydrogen maleate;Timolol maleate salt

CAS NO.：26921-17-5

Empirical Formula: C17H28N4O7S

Molecular Weight: 432.49

MDL number: MFCD00058356

EINECS: 248-111-5

PRODUCT Properties

• Melting point: 202-203 °C(lit.)
• alpha: 24405 -12.0° (c = 5 in 1N HCl); D25 -4.2°
• storage temp.: 2-8°C
• solubility: H₂O: soluble
• form: powder
• color: white to off-white
• optical activity: [α]25/D -5.4°, c = 4.9 in 1 M HCl(lit.)
• Merck: 14,9444
• InChIKey: WLRMANUAADYWEA-NWASOUNVSA-N

Description and Uses

Timolol is a non-selective β-adrenergic receptor antagonist with log K_d values of -8.27, -9.86, and -6.8 for binding to human β₁-, β₂-, and β₃-adrenoceptors, respectively. It has been reported that only the (S) enantiomer contributes to the β-blocking effects of racemic timolol, but the weakly active (R) isomer maintains a beneficial effect on intraocular pressure without the undesirable side-effect of bronchial constriction caused by non-selective action of (S)-timolol on β₁ and β₂ receptors. Timolol has been use alone and in fixed combinations with either prostaglandin analogs or carbonic anhydrase inhibitors to reduce intraocular pressure in research models of ocular hypertension and glaucoma.

Anti hypertensive, Anti-glaucoma

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Warning
• Hazard statements: H302-H361
• Precautionary statements: P280-P301+P312+P330
• Hazard Codes: Xn,Xi
• Risk Statements: 22-63-36/37/38
• Safety Statements: 36-37/39-26
• WGK Germany: 3
• RTECS: UA8475000
• HS Code: 29349990