Synephrinehydrochloride , 95% , 5985-28-4
CAS NO.：5985-28-4
Empirical Formula: C9H14ClNO2
Molecular Weight: 203.67
MDL number: MFCD00050566
EINECS: 227-804-6
| Pack Size | Price | Stock | Quantity |
| 10g | RMB88.00 | In Stock |
|
| 50g | RMB364.80 | In Stock |
|
| 250g | RMB1440.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 147-150°C |
| storage temp. | Refrigerator |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | Off-White to Pale Beige |
| InChI | InChI=1S/C9H13NO2.ClH/c1-10-6-9(12)7-2-4-8(11)5-3-7;/h2-5,9-12H,6H2,1H3;1H |
| InChIKey | COTCEGYSNTWJQV-UHFFFAOYSA-N |
| SMILES | C1(=CC=C(O)C=C1)C(O)CNC.Cl |
| LogP | -0.030 (est) |
| CAS DataBase Reference | 5985-28-4(CAS DataBase Reference) |
Description and Uses
(±)-Synephrine is an alkaloid with vasoconstrictor and metabolic activities. It binds to α1A-, α2A-, and α2C-adrenergic receptors (ARs; Kis = 78, 36.7, and 24.4 μM, respectively). (±)-Synephrine is an agonist of α1A-ARs in HEK293 cells (EC50 = 4 μM in a reporter assay) but not in CHO cells expressing α2A- or α2C-AR. It also acts as an antagonist of α1A-, α2A-, and α2C-ARs, inhibiting L-phenylephrine-induced activation of α1A-AR in HEK293 cells and activation of α2A- and α2C-ARs induced by the α2-AR agonist medetomidine in CHO cells (IC50s = 12.8, 26, and 27.3 μM, respectively, in reporter assays). (±)-Synephrine induces contractions in isolated rabbit aortic rings (EC50 = 6.2 μg/ml) and increases ligation-induced mean arterial pressure in rats when administered at a dose of 2 mg/kg per day. It induces lipolysis in isolated rat and human adipocytes when used at concentrations of 100 and 1,000 μg/ml. (±)-Synephrine (50 μM) increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, as well as increases insulin-induced glucose consumption in L6 muscle cells when used at concentrations ranging from 25 to 200 μM.
A α-adrenergic receptor agonist, vasoconstrictor.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H335-H319 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| HS Code | 2922498590 |
