Ro48-8071? , 98% , 161582-11-2

CAS NO.：161582-11-2

Empirical Formula: C23H27BrFNO2

Molecular Weight: 448.37

MDL number: MFCD08062177

PRODUCT Properties

• Boiling point: 522.8±50.0 °C(Predicted)
• Density: 1.235±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:2): .25 mg/ml
• pka: 8.88±0.50(Predicted)

Description and Uses

Oxidosqualene cyclase (OSC) is a microsomal enzyme that catalyzes the cyclization of monooxidosqualene to lanosterol in the cholesterol synthetic pathway. Ro 48-8071 is an inhibitor of oxidosqualene cyclase (OSC) that has low-density lipoprotein (LDL) cholesterol lowering activity similar to the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) inhibitor simvastatin. It inhibits OSC from human liver microsomes and HepG2 cells with IC₅₀ values of approximately 6.5 nM and 1.5 nM, respectively. Ro 48-8071 lowered LDL cholesterol ~40% in hamsters at a dose of 150 μg/kg without affecting high-density lipoprotein levels and with no sign of liver toxicity. Ro 48-8071 increases cytochrome P3A mRNA and protein levels in primary rat and murine hepatocyte cultures with a maximal effect at 30 μM.

Ro 48-8071 is an inhibitor of oxidosqualene cyclase.

Safety

• Symbol(GHS): GHS02,GHS07
• Signal word: Danger
• Hazard statements: H225-H319-H336
• Precautionary statements: P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501