RegorafenibMonohydrate , 99% , 1019206-88-2

Synonym(s):
4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide monohydrate

CAS NO.：1019206-88-2

Empirical Formula: C21H17ClF4N4O4

Molecular Weight: 500.83

MDL number:

EINECS: 1308068-626-2

PRODUCT Properties

• storage temp.: 2-8°C
• solubility: ≥25.05 mg/mL in DMSO; insoluble in H2O
• form: solid
• color: Light yellow to orange
• InChIKey: ZOPOQLDXFHBOIH-UHFFFAOYSA-N
• SMILES: O(C1C=CC(NC(=O)NC2C=CC(Cl)=C(C(F)(F)F)C=2)=C(F)C=1)C1=CC=NC(C(=O)NC)=C1.O

Description and Uses

Regorafenib monohydrate (BAY 73-4506) is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor with potent anti-tumour and anti-angiogenic activity. It is approved for the treatment of metastatic colorectal cancer, advanced gastrointestinal mesenchymal stromal tumours and hepatocellular carcinoma.

4-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide Hydrate can be used as an anti-tumor drug.

Safety

• Symbol(GHS): GHS08,GHS09
• Signal word: Warning
• Hazard statements: H361fd-H373-H410
• Precautionary statements: P201-P273-P308+P313