RG7227 , 95% , 850876-88-9

CAS NO.：850876-88-9

Empirical Formula: C35H46FN5O9S

Molecular Weight: 731.83

MDL number:

PRODUCT Properties

• Melting point: >165°C (dec.)
• Density: 1.41
• storage temp.: -20°C Freezer
• solubility: Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
• form: Solid
• pka: 4.43±0.60(Predicted)
• color: White to Pale Beige
• InChIKey: ZVTDLPBHTSMEJZ-AIYSODCISA-N
• SMILES: C1C2=C(C(F)=CC=C2)CN1C(O[C@H]1CN2C(=O)[C@@H](NC(OC(C)(C)C)=O)CCCCCC=C[C@]3([H])C[C@@]3(C(NS(C3CC3)(=O)=O)=O)NC(=O)[C@]2([H])C1)=O |t:33|

Description and Uses

Danoprevir is an orally bioavailable inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A; IC₅₀ = 1 nM), a serine protease essential for HCV replication. It is selective for NS3/4A over a panel of 53 proteases at a concentration of 10 μM. Danoprevir inhibits replication of the HCV genotypes 1a, 1b, 4, 5, and 6 (IC₅₀s = 0.2-0.4 nM) as well as 2b and 3a (IC₅₀s = 1.6 and 3.5 nM, respectively) in vitro. It also reduces the number of HCV genotype 1b replicons in Huh-7 cells (EC₅₀ = 1.8 nM).

Danoprevir is a selective and potent inhibitor of Hepatitis C virus.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P280-P305+P351+P338