Pivmecillinam , 98% , 32886-97-8

Synonym(s):
Amdinocillin pivoxil

CAS NO.：32886-97-8

Empirical Formula: C21H33N3O5S

Molecular Weight: 439.57

MDL number: MFCD00865080

EINECS: 251-276-6

PRODUCT Properties

• Melting point: 118-119 C
• alpha: D20 +231° (c = 1 in 96% ethanol)
• Boiling point: 581.0±60.0 °C(Predicted)
• Density: 1.30±0.1 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: DMSO: soluble5mg/mL, clear (warmed)
• form: powder
• pka: 8.11±0.60(Predicted)
• color: white to beige
• optical activity: [α]/D +215 to +245°, c = 1 in ethanol

Description and Uses

Pivmecillinam was found by a series of studies at Leo in 1969. It is a derivative of 6βformamidinopenicillanic acid and shows strong activity against gram-negative bacilli. Pivmecillinam is hydrolyzed by intestinal esterase and acts similarly to mecillinam after oral administration. Mecillinam shows weaker activity than ampicillin against gram-positive cocci but much stronger activity against a wide range of gramnegative bacilli.

Antibacterial.

Safety

• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• RTECS: XI0185000
• Toxicity: LD50 in mice, rats (mg/kg): 475-480, 465 i.v.; 1736-1930, 1935-2100 s.c.; 3020, 9500-10000 orally (Sato)