ChromomycinA? , 90% , 7059-24-7
Synonym(s):
Aburamycin B;Chromomycin A₃ - CAS 7059-24-7 - Calbiochem;CMA3;NSC 58514;Toyomycin
CAS NO.：7059-24-7
Empirical Formula: C57H82O26
Molecular Weight: 1183.25
MDL number: MFCD00043151
EINECS: 230-348-0
| Pack Size | Price | Stock | Quantity |
| 10mg | RMB2456.80 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 185℃ |
| alpha | D23 -57° (ethanol) |
| Boiling point: | 780.13°C (rough estimate) |
| Density | 1.1451 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in ethanol, DMSO, and ethyl acetate (10 mg/ml). |
| form | Yellow solid |
| pka | 4.54±0.60(Predicted) |
| color | Yellow |
| Merck | 13,2258 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
Description and Uses
Chromomycin A3 is an anthraquinone antibiotic and antitumor agent isolated from S. griseus that is used as a fluorescent probe for DNA with excitation/emission spectra of 445/575 nm. Its DNA binding is specific to two or more contiguous GC base pairs, which makes it suitable for characterizing heterochromatin in plants with species-specific AT:GC ratios. Chromomycin A3 is cytotoxic against non-small cell lung cancer and cervical cancer in vitro (IC50s = 1, 42, 60, and 40 nM for HCC44, A549, ME180, and HeLa cells, respectively). It also inhibits oxidative stress- and DNA damage-induced neuronal injury by enhancing Sp1 and Sp3 transcription factor binding.
Chromomycin A3, is used as a G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye. Chromomycin A3 antagonizes enhanced DNA binding of the transcription factors Sp1 and Sp3 to their cognate "G-C" box, induced by oxidative stress or DNA damage. Furthermore, by inhibiting transcription, Chromomycin A3 and its structural analogs can inhibit protein biosynthesis.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H300 |
| Precautionary statements | P264-P270-P301+P310-P405-P501 |
| Hazard Codes | T+,T |
| Risk Statements | 61-28 |
| Safety Statements | 53-28-36/37/39-45 |
| RIDADR | UN 3462 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | GB7875000 |
| F | 3-8-10 |
| HazardClass | 6.1(a) |
| PackingGroup | I |
| HS Code | 29419090 |
| Toxicity | Excitation max: ~445 nm. Emission max: ~575 nm. Sol in ethanol, ethyl acetate, DMSO, methanol. LD50 in mice (mg/kg): 1.85 i.v. (Slavik, Carter). |
