Echinomycin , ≥98% , 512-64-1

Synonym(s):
Echinomycin Streptomyces sp. - CAS 512-64-1 - Calbiochem;NSC-13502, Quinomycin A;Quinomycin A

CAS NO.：512-64-1

Empirical Formula: C51H64N12O12S2

Molecular Weight: 1101.26

MDL number: MFCD00156105

PRODUCT Properties

• Melting point: 217-218℃
• alpha: D20 -310° (c = 0.86 in chloroform)
• Boiling point: 1427.2±65.0 °C(Predicted)
• Density: 1.0964 (rough estimate)
• refractive index: 1.6700 (estimate)
• storage temp.: -20°C
• solubility: Soluble in DMSO (up to 5 mg/ml)
• pka: 9.38±0.70(Predicted)
• form: White solid
• color: white to beige
• Merck: 13,3531
• Stability: Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months

Description and Uses

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that controls genes involved in glycolysis, angiogenesis, migration, and invasion. Echinomycin is a cell-permeable inhibitor of HIF-1-mediated gene transcription. It acts by intercalating into DNA in a sequence-specific manner, blocking the binding of either HIF-1α or HIF-1β to the hypoxia-responsive element. Echinomycin reversibly inhibits hypoxia-induced HIF-1 transcription activity in U215 cells with an EC₅₀ value of 1.2 nM. It inhibits hypoxia-induced expression of vascular endothelial growth factor, blocking angiogenesis and altering excitatory synaptic transmission in hippocampal neurons. Echinomycin also impairs expression of survivin, enhancing the sensitivity of multiple myeloma cells to melphalan.

Quinomycin A is a cyclic depsipeptide metabolite. Quinomycin A has broad activity against bacteria, fungi and viruses, and has found application as an antitumor agent. Quinomycin A acts by bifunctional intercalation of nucleic acids. Recent research has shown quinomycin A to be an extremely potent inhibitor of hypoxia-inducible factor-1 (HIF-1). This transcription factor plays an essential role in tumor progression and metastasis.

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H301+H311+H331-H361
• Precautionary statements: P201-P202-P280-P301+P310-P302+P352+P312-P304+P340+P311
• Hazard Codes: T
• Risk Statements: 46-23/24/25
• Safety Statements: 53-36/37/39-45
• RIDADR: UN 3462 6.1/PG 2
• WGK Germany: 3
• RTECS: JW5250000
• F: 10
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 2941900000