AmifostineTrihydrate , 10mMinWater , 112901-68-5
CAS NO.：112901-68-5
Empirical Formula: C5H17N2O4PS
Molecular Weight: 232.23
MDL number: MFCD00233058
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB239.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| storage temp. | 2-8°C |
| solubility | PBS (pH 7.2): 5 mg/ml |
| form | powder |
| pka | pKa1 <2.0; pKa2 4.2; pKa3 9.0; pKa4 11.7(at 25℃) |
| color | White to off-white |
| InChIKey | JKOQGQFVAUAYPM-UHFFFAOYSA-N |
| CAS DataBase Reference | 112901-68-5(CAS DataBase Reference) |
Description and Uses
Amifostine is a broad-spectrum cytoprotective agent, once used as a military anti-radiation agent, and now used as a protective drug for radiotherapy and chemotherapy. It has significantly effective in reducing the side effects of anticancer drugs such as cyclophosphamide, ciplatin, doxorubicin, and anti-HIV drugs such as 3-azido-3-deoxythymidine, without affecting the efficacy of anticancer or anti-HIV drugs curative effect. At present, the commercially available amifostine products include freeze-dried powder injection（ETHYOL ）produced by American Life Sciences Co., Ltd. It is only available as a lyophilized powder for injection, but is thermally unstable.
Amifostine may provide renal protection during PRRT using somatostatin analogs by mitigating radiation damage and reducing the absorbed kidney radiation dose. Amifostine remediates the degenerative effects of radiation on the mineralization capacity of the murine mandible.
