NS1738 , ≥99% , 501684-93-1
CAS NO.：501684-93-1
Empirical Formula: C14H9Cl2F3N2O2
Molecular Weight: 365.13
MDL number: MFCD11100189
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB500.00 | In Stock |
|
| 10mg | RMB758.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 344.1±42.0 °C(Predicted) |
| Density | 1.617±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | White crystalline solid. |
| pka | 8.08±0.13(Predicted) |
| color | Off-White to Light Grey |
Description and Uses
NS 1738 is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs). When applied in the presence of ACh, NS 1738 increases the peak amplitude of the current flowing through α7-containing nAChRs (EC50 = 3.4 μM). NS 1738 displays no substantial activity for α4β2-, α3β3-, and α1-containing receptors. It is modestly brain-penetrant and counteracts (-)-scopolamine-induced deficit in acquisition of a water-maze learning task in rats. NS 1738 also improves performance in the rat social recognition test. NS 1738 is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.
NS 1738 is a selective a7 nAchR allosteric modulator.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P305+P351+P338 |
