Home Categories 7α-hydroxycholesterol-d7
M4390753

7α-hydroxycholesterol-d7 , >99%(TLC) , 349553-94-2

Synonym(s):
cholest-5-ene-3b,7a-diol(d7); 110971

CAS NO.:349553-94-2

Empirical Formula: C26H37D7O2

Molecular Weight: 395.67

MDL number: MFCD01317395

Pack Size Price Stock Quantity
1mg RMB4619.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

storage temp.  -20°C
solubility  DMF: 2 mg/ml; DMSO: 0.1 mg/ml; Ethanol: 20 mg/ml
form  A solid
color  White to off-white

Description and Uses

7α-hydroxy Cholesterol-d7 is intended for use as an internal standard for the quantification of 7α-hydroxy cholesterol by GC- or LC-MS. 7α-hydroxy Cholesterol is an oxysterol and a precursor in the biosynthesis of the bile acids cholic acid (CA; ) and chenodeoxycholic acid (CDCA; ). It is formed via the oxidation of cholesterol by cholesterol 7α-hydroxylase/CYP7A1 in rat liver microsomes. 7α-hydroxy Cholesterol (40 μM) increases levels of the adhesion molecules ICAM-1, VCAM-1, and E-selectin in human umbilical vein endothelial cells (HUVECs). It increases secretion of chemokine (C-C motif) ligand 2 (CCL2) and matrix metalloproteinase-9 (MMP-9) in serum-deprived THP-1 cells when used at a concentration of 5 μg/ml. 7α-hydroxy Cholesterol has been found in macrophages isolated from atherosclerotic lesions in rabbits fed a high-cholesterol diet.

7α-hydroxycholesterol-d7 has been used as an internal standard for cholesterol and oxysterol measurement by gas chromatography-mass spectrometry (GC/MS).

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