HydroxyItraconazole , ≥99% , 112559-91-8

CAS NO.：112559-91-8

Empirical Formula: C35H38Cl2N8O5

Molecular Weight: 721.63

MDL number: MFCD00871966

PRODUCT Properties

• Melting point: 76-78°C
• Boiling point: 884.7±75.0 °C(Predicted)
• Density: 1.44±0.1 g/cm3(Predicted)
• storage temp.: -20°C Freezer
• solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• form: Solid
• pka: 14.72±0.20(Predicted)
• color: White to Pale Beige

Description and Uses

Hydroxy itraconazole (OH-ITZ) is an active metabolite of the antifungal agent itraconazole . Itraconazole is metabolized by the cytochrome P450 isoform 3A4 (CYP3A4) to form hydroxy itraconazole. Hydroxy itraconazole exhibits in vitro antifungal activity (MIC = 0.019, 0.078, and 0.078 mg/ml against C. albicans, A. fumigatus, and C. neoformans, respectively). Plasma concentration of hydroxy itraconazole is directly correlated to that of the parent compound and is used as an indicator of prophylaxis for fungal infections.

A metabolite of Itraconazole, an orally active antimycotic structurally related to Ketoconazole. It is a COVID19-related research product.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501