Itraconazole , 2mMinDMSO , 84625-61-6

Synonym(s):
;Itraconazole;Oriconazole;Sporanox

CAS NO.：84625-61-6

Empirical Formula: C35H38Cl2N8O4

Molecular Weight: 705.63

MDL number: MFCD08064196

EINECS: 617-596-9

PRODUCT Properties

• Melting point: 166°C
• Boiling point: 850.0±75.0 °C(Predicted)
• alpha: -0.1～+0.1°(D/20℃)(c=10,CH2Cl2)
• Density: 1.27 g/cm3
• Flash point: >110°(230°F)
• storage temp.: 2-8°C
• solubility: chloroform: 50 mg/mL, clear, colorless
• pka: 3.7(at 25℃)
• form: White powder
• color: white
• Water Solubility: Insoluble in water. Solube in chloroform at 50 mg/ml. Slightly soluble in ethanol or methanol
• Merck: 14,5245
• Stability: Stable. Incompatible with strong oxidizing agents.
• InChIKey: VHVPQPYKVGDNFY-UHFFFAOYSA-N
• CAS DataBase Reference: 84625-61-6(CAS DataBase Reference)

Description and Uses

Itraconazole is an orally-active triazole antifungal indicated for use in the treatment of dermal, vaginal and systemic mycoses. In immunocompromised and AIDS patients, itraconazole has been shown to significantly reduce the incidence of relapses of cryptococcal meningitis.

A traizole antifungal agent

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
• Hazard Codes: Xi,Xn,T,F
• Risk Statements: 36/37/38-36/38-22-39/23/24/25-23/24/25-11
• Safety Statements: 22-26-36-45-36/37-16
• RIDADR: UN 3286 8(6.1)(3) / PGII
• WGK Germany: 3
• RTECS: XZ5481000
• HS Code: 2934990002
• Hazardous Substances Data: 84625-61-6(Hazardous Substances Data)
• Toxicity: LD50 (14 day) in mice, rats, dogs (mg/kg): >320, >320, >200 orally (Van Cauteren)