Hydrastine , ≥99% , 118-08-1

Synonym(s):
(1R,9S)-(−)-β-Hydrastine

CAS NO.：118-08-1

Empirical Formula: C21H21NO6

Molecular Weight: 383.39

MDL number: MFCD00152561

EINECS: 204-233-0

PRODUCT Properties

• Melting point: 132℃
• alpha: D20 -50° (c = 0.3 in abs alc)
• Boiling point: 510.32°C (rough estimate)
• Density: 1.339±0.06 g/cm3 (20 ºC 760 Torr)
• refractive index: 1.5614 (estimate)
• storage temp.: −20°C
• solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml
• form: A crystalline solid
• pka: 7.8(at 25℃)
• color: White to light yellow
• Water Solubility: 30mg/L(20 ºC)
• CAS DataBase Reference: 118-08-1(CAS DataBase Reference)

Description and Uses

(1R,9S)-(–)-β-Hydrastine is an enantiomer of the alkaloid hydrastine that inhibits dopamine biosynthesis (IC₅₀ = 20.7 μM in PC12 cells) by inhibiting tyrosine hydroxylase activity. It inhibits dopamine release with an IC₅₀ value of 66.5 μM in the presence of high extracellular K⁺ levels. It also inhibits L-type and caffeine-activated store-operated Ca²⁺ channels and prevents Ca²⁺ leakage from intracellular stores.

(-)-β-Hydrastine is an inhibitor of Dopamine biosynthesis.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P301+P312+P330
• Hazard Codes: Xn
• Risk Statements: 20/21/22
• Safety Statements: 36
• RIDADR: 1544
• WGK Germany: 3
• RTECS: MU6030000
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 2939800000